Prevalence of CagA and VacA antibodies in children with Helicobacter pylori-associated peptic ulcer compared to prevalence in pediatric patients withactive or nonactive chronic gastritis

Authors
Alarcon, T Martinez, MJ Urruzuno, P Cilleruelo, ML Madruga, D Sebastian, M Domingo, D Sanz, JC Lopez-Brea, M
Citation
T. Alarcon et al., Prevalence of CagA and VacA antibodies in children with Helicobacter pylori-associated peptic ulcer compared to prevalence in pediatric patients withactive or nonactive chronic gastritis, CL DIAG LAB, 7(5), 2000, pp. 842-844
Citations number
19
Categorie Soggetti
Immunology
Journal title
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
ISSN journal
1071412X → ACNP
Volume
7
Issue
5
Year of publication
2000
Pages
842 - 844
Database
ISI
SICI code
1071-412X(200009)7:5<842:POCAVA>2.0.ZU;2-I
Abstract
VacA and CagA serological responses were detected in pediatric patients: 44 and 56%, respectively, in peptic ulcer (PU) patients, 33.3 and 44.4% in ac tive chronic gastritis (ACG) patients, and 23.2 and 39.2% in non-ACG patien ts. Higher seroprevalence to CagA+VacA and to CagA+VacA+35-kDa antigen was found among PU patients. However, a low level of sensitivity and specificit y was found for indirect detection of PU patients.