Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: Specific effect of HAART on neopterin

Authors
Amirayan-Chevillard, N Tissot-Dupont, H Obadia, Y Gallais, H Mege, JL Capo, C
Citation
N. Amirayan-chevillard et al., Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: Specific effect of HAART on neopterin, CL DIAG LAB, 7(5), 2000, pp. 832-834
Citations number
21
Categorie Soggetti
Immunology
Journal title
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
ISSN journal
1071412X → ACNP
Volume
7
Issue
5
Year of publication
2000
Pages
832 - 834
Database
ISI
SICI code
1071-412X(200009)7:5<832:HAAT(A>2.0.ZU;2-B
Abstract
The circulating levels of immune activation markers, including neopterin, t umor necrosis factor receptor type II, and interleukin-2 receptors, are inc reased in human immunodeficiency virus-infected patients. We show here that highly active antiretroviral therapy significantly decreased neopterin lev els. This effect is reversible, since neopterin levels increased after the arrest of treatment. Their determination may be useful in the evaluation of the efficacy of antiretroviral therapy.