Effects of charge density and hydrophobicity of ionene polymer on cell binding and viability

Citation
T. Narita et al., Effects of charge density and hydrophobicity of ionene polymer on cell binding and viability, COLLOID P S, 278(9), 2000, pp. 884-887
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
COLLOID AND POLYMER SCIENCE
ISSN journal
0303402X → ACNP
Volume
278
Issue
9
Year of publication
2000
Pages
884 - 887
Database
ISI
SICI code
0303-402X(200009)278:9<884:EOCDAH>2.0.ZU;2-0
Abstract
The binding of cationic ionenes onto budding protoplast was investigated an d the results were associated with the cell viability. There are critical n umbers of carbon atoms to induce effective cell disruption and cell binding . The longer the alkyl chain of the ionene, the lower the concentration at which cell disruption occurs. The ionenes with increased charge density und ergo effective binding, while almost 2 orders of magnitude higher concentra tion are required for effective cell disruption. These results were associa ted with the cooperativity of the binding process, which induces local stre ss and solubilization of the lipid membrane.