Commercially available infant formulas serve as the best alternative to hum
an milk when breastfeeding is not possible. Infant formulas are designed sp
ecifically to mimic the composition of human milk or the functional aspects
of human milk feeding. This review highlights the issues related to the co
mposition of infant formulas. The most hotly debated issue currently is whe
ther to add long-chain polyunsaturated fatty acids to infant formulas. Othe
r controversial topics include the safety and efficacy of soy-based protein
formulas, protein quantity and quality as they relate to the infant's nutr
itional needs and feeding tolerance, and the replacement of lactose with ot
her carbohydrate sources for specialized infant formulas, Recent modificati
ons in the fat blend of infant formulas have led to improved fat digestibil
ity. However, the full spectrum of benefits associated with the addition-oi
nucleotides. awaits further study. Modifications to infant formulas are ma
de when the preponderance of scientific evidence suggests that the composit
ional change will better meet the nutritional needs of the infant, (C) 2000
Lippincott Williams & Wilkins, Inc.