Jp. Bastard et al., Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity, DIABET OB M, 2(5), 2000, pp. 323-325
The aim of this study was to investigate the variations in the plasma level
s of the soluble tumour necrosis factor receptor type-I (sTNFR-I) and type-
II (sTNFR-II) during weight loss which was induced by 3 weeks on a very low
calorie diet (3.9 +/- 0.1 MJ/day), in 17 non-diabetic obese women. Plasma
sTNFR-I concentrations decreased significantly after weight loss (p < 0.05)
, but there was no significant change in plasma sTNFR-II. As the diet was a
ssociated with a significant decrease in body fat mass (approximate to 2.5
kg), this result supports the emerging concept that adipose tissue can prod
uce significant amounts of sTNFR-I and that this production can be modified
by weight loss in human obesity.