The gasoline oxygenate MTBE (methyl tert-butyl ether) was widely adopted ac
ross the United States in the 1990s as a key component of federally mandate
d oxygenated and reformulated fuels. The regulations implementing statutory
mandates for oxygenated fuels were promulgated without a comprehensive eva
luation of the environmental or health consequences of using MTBE or other
oxygenates in such large quantities. Policymakers only belatedly realized t
he environmental ramifications of increased levels of MTBE in gasoline, esp
ecially groundwater contamination resulting from leaking fuel tanks. The po
licy process that led to MTBE's predominance was flawed, since no systemati
c attempt was made a priori to evaluate multimedia implications of MTBE's w
idespread use. The history of MTBE in the United States illustrates several
typical, but problematic, features of environmental policymaking. It revea
ls how the scale of chemical usage directly impacts actual and perceived en
vironmental effects. It highlights how institutional factors constrain poli
cymakers through statutory mandates, regulatory agency organizational struc
tures, and the strong influence exerted by political-economic actors even i
n supposedly "technical" debates. Finally, the MTBE case reveals barriers t
o effective scientific and technical communications among policymakers, reg
ulated industries, special-interest groups, and the public.