A 22-year-old male presented with a 1-year history of nasal obstruction due
to a polypoid mass in the right nasal cavity. Histopathologic examination
revealed the tumor to consist of a mixture of a trabecular structure with a
double-layered arrangement of inner dark cells and outer clear cells. Immu
nohistochemical examination showed the clear cells to be positive for alpha
-smooth muscle actin and S-100 protein. Ultrastructural examination confirm
ed the myoepithelial cell origin. The tumor was excised and no recurrence o
r metastasis was found 40 months after surgery. We describe here a rare cas
e of epithelial-myoepithelial carcinoma arising from the nasal cavity, one
of the most unusual locations.