Cytoskeleton actin changes in IL-2 activated cells

In the present study we analysed the changes in cytoskeleton actin in lymph oid cells following IL-2 activation and during cell interactions by means o f light and electron microscopy, immunofluorescence and molecular analysis. By morphological analysis we observed a higher fluorescence in the activat ed cells than in the quiescent ones with no modifications in the cytoskelet on pattern comparing activated to resting cells. The results of molecular a nalysis indicate that, after IL-2 activation, there is a reorganisation of the actin component of the cell cytoskeleton accompanied by the differentia l expression of the corresponding genes. A future study will be extended to the analysis of others components of the cytoskeleton network.