Objective. The aims of this study were to evaluate psychological distress a
nd quality of life (QOL) in patients with epithelial ovarian cancer (EOC) a
nd to examine the relationship between these problems and health and demogr
aphic variables.
Methods. Of 344 consecutive patients identified, 246 completed questionnair
es. Four dimensions of QOL were assessed including physical, functional, em
otional, and social/family well-being, as well as concerns specific to ovar
ian cancer patients. Depression was measured with the Center for Epidemiolo
gic Studies-Depression (CES-D) scale and anxiety was measured by the State
Anxiety Subscale of the Spielberger State-Trait Anxiety Inventory. Performa
nce status was evaluated by the Zubrod score.
Results. Sixty-five patients (26%) had early stage disease; 181 (74%) had a
dvanced disease. One hundred twenty-one patients (49%) were under active tr
eatment, while 124 (51%) were seen for posttherapy surveillance. Forty-eigh
t (21%) met CES-D cutoff criteria for a clinical evaluation for depression,
and 29% scored above the 75th percentile for anxiety. Performance status w
as related to depression, anxiety, and QOL problems, except in the domain o
f social well-being.
Conclusions. Clinically significant depression and anxiety may be more prev
alent in patients with EOC than previously reported. Future studies of scre
ening for and treating psychological distress are being designed to improve
QOL in these women. (C) 2000 Academic Press.