Molecular and clinical prognostic factors in BFM-treated childhood acute lymphoblastic leukemia patients: a single institution series

Authors
Ruano, D Diaz, MA Tutor, O Garcia-Sanchez, F Martinez, P Madero, L
Citation
D. Ruano et al., Molecular and clinical prognostic factors in BFM-treated childhood acute lymphoblastic leukemia patients: a single institution series, HAEMATOLOG, 85(8), 2000, pp. 877-878
Citations number
10
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
8
Year of publication
2000
Pages
877 - 878
Database
ISI
SICI code
0390-6078(200008)85:8<877:MACPFI>2.0.ZU;2-Q
Abstract
We analyzed the impact on outcome of minimal residual disease (MRD) and cli nical factors in 97 children with acute lymphoblastic leukemia. Unfavorable factors were early-B and -T immunophenotype, hyperleukocytosis, non-respon se to steroids, detection of MRD at the end of induction therapy. A level o f MRD greater than or equal to 1/10(3) leads to a lower probability of dise ase-free survival.