Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma by combined methotrexate and prednisone

Authors
Quintini, G Barbera, V Ammatuna, E Franco, V Florena, AM Mariani, G
Citation
G. Quintini et al., Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma by combined methotrexate and prednisone, HAEMATOLOG, 85(8), 2000, pp. 880-881
Citations number
7
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
8
Year of publication
2000
Pages
880 - 881
Database
ISI
SICI code
0390-6078(200008)85:8<880:STOALW>2.0.ZU;2-Q
Abstract
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)-type T-cell l ymphoma has a very poor prognosis in most patients. Here we report a comple te clinical response in a patient treated with low-dose oral methotrexate ( 10 mg/m(2) weekly) in combination with prednisone (15 mg/day) in whom conve ntional chemotherapy was not effective. This regimen was not associated wit h major side effects, Our findings suggest that methotrexate may have benef icial effects in AILD-type T-cell lymphoma. Pilot clinical trials ave neede d to verify its efficacy in this setting.