Antibiotic sensitivity of Neisseria gonorrhoeae isolates in Berlin

Background and Objective. Because of the increasing resistance of Neisseria gonorrhoeae,we studied the actual resistance do isolats in Berlin. Patients/Methods. 85 Neisseria gonorrhoeae isolates were collected between 1995 and 1997. Susceptibility testing was perform ed for penicillin G, tetr acycline, spectinomycin, ceftriaxon, ciprofloxacin and azithromycin by agar dilution. Results. 18.8% isolates were resistant or intermediately resistant to penic illin G (including 6 PPNG). 12.9% isolates were resistant, 43.5% intermedia tely resistant to tetracyclin. One strain was resistant against ciprofloxac in, 4, isolates showed increased MIC values (0.06-0.5 mg/l),whereas 78 isol ates were fully susceptible (<0.007 mg/l). All isolates were susceptible to spectinomycin, ceftriaxone, and azithromycin. Conclusions. Penicillin G and tetracycline should be given only in cases of proven sensibility. Resistance against ciprofloxacin may occur, especially in isolates aquired in south-east Asia. Ceftriaxone, spectinomycin and azi thromycin were active against all isolates. The actual resistance situation should be monitored.