Lack of correlation between serum levels of E- and P-cadherin fragments and the presence of breast cancer

Breast cancers often show reduced expression of the transmembrane cell-cell adhesion protein, E-cadherin, In addition, approximately half of breast ca rcinomas express P-cadherin, which correlates with poor survival. A large f ragment of the E-cadherin extracellular domain can be detected in serum, an d it has been proposed that an increase in serum E-cadherin can denote the presence of a tumor. In this study, we tested the possibility that serum E- or P-cadherin levels might be useful diagnostic or prognostic indicators i n breast cancer. However, we found no indication that the level of serum E- cadherin correlated with the presence of breast cancer. In addition, althou gh we successfully detected a fragment of P-cadherin in serum, we found tha t its level was considerably lower than that of E-cadherin and did not corr elate with the presence of P-cadherin-positive breast cancer. Copyright (C) 2000 by W.B. Saunders Company.