Leukocyte recruitment during pulmonary Cryptococcus neoformans infection

Leukocyte recruitment to the site of infection by the encapsulated yeast Cr yptococcus neoformans is critical for clearance of the infection. We review data from our lab that chemokines, such as the CC chemokines MCP-1 and MIP -1 alpha, are important mediators of leukocyte recruitment during C. neofor mans infection. In addition, studies in CC chemokine receptor knockout mice have demonstrated that CCR2 and CCR5 are required not only for leukocyte r ecruitment but also for other aspects of immune response development and in nate imunity to C. neoformans. (C) 2000 Elsevier Science B.V. All rights re served.