Diesel exhaust as a model xenobiotic in allergic inflammation

Authors
Saxon, A Diaz-Sanchez, D
Citation
A. Saxon et D. Diaz-sanchez, Diesel exhaust as a model xenobiotic in allergic inflammation, IMMUNOPHARM, 48(3), 2000, pp. 325-327
Citations number
10
Categorie Soggetti
Immunology
Journal title
IMMUNOPHARMACOLOGY
ISSN journal
01623109 → ACNP
Volume
48
Issue
3
Year of publication
2000
Pages
325 - 327
Database
ISI
SICI code
0162-3109(20000725)48:3<325:DEAAMX>2.0.ZU;2-Y
Abstract
We investigated the effects of diesel exhaust particulates on the human all ergic response using in vivo human nasal challenges. Diesel particles and p henanthrene, one of their constituent polyaromatic hydrocarbons, were shown to enhance total allergic antibody (IgE) production, enhance allergen-spec ific IEE in the presence of allergen, and induce sensitization to a neoanti gen. (C) 2000 Elsevier Science B.V. All rights reserved.