In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide

The antifungal activity of FK463 against 72 recent clinical isolates of Can dida albicans (24), Candida glabrata (17), Candida tropicalis (11), Candida krusei (8) and Candida parapsilosis (12) was compared with those of amphot ericin B, fluconazole and itraconazole by means of a broth microdilution me thod specified by the National Committee for Clinical Laboratory Standards (NCCLS) document M27-A. The lowest drug concentration at which 90% of the p opulation was inhibited (MIC90) of FK463 against C. albicans, C. glabrata, C. tropicalis, C. krusei and C. parapsilosis was 0.0156, 0.0156, 0.0313, 0. 125 and 1 mg/L, respectively. FK463 exhibited broad-spectrum activity again st clinically important Candida spp. (MIC range less than or equal to 0.003 9-2 mg/L), and its MICs for such fungi were lower than those of other antif ungal agents tested. The minimum fungicidal concentrations for Candida spp, did not differ by more than two-fold from the MICs. Results from pre-clini cal evaluations performed to date indicate that FK463 should be a potent pa renteral antifungal agent.