Jeg. Sanchez et al., Susceptibility of Helicobacter pylori to mupirocin, oxazolidinones, quinupristin/dalfopristin and new quinolones, J ANTIMICRO, 46(2), 2000, pp. 283-285
The in vitro activities of mupirocin, quinupristin/dalfopristin, linezolid,
eperezolid, sitafloxacin, clinafloxacin, moxifloxacin, amoxycillin, metron
idazole and clarithromycin were tested at pH 7.4 against 57 strains of Heli
cobacter pylori. The most active agents (mupirocin, sitafloxacin and clinaf
loxacin) were also tested for activity at pH 5.4 against the same strains,
Mupirocin was very active at pH 7.4 and 5.4 (MIC90 0.25 and 0.12 mg/L, resp
ectively). Quinupristin/dalfopristin, linezolid and eperezolid had low acti
vity (MIC90 4, 8 and 4 mg/L, respectively), Sitafloxacin (MIC90 less than o
r equal to 0.008 mg/L) was the most active fluoroquinolone, while clinaflox
acin (MIC90 0.12 mg/L) and moxifloxacin (MIC90 2 mg/L) were least active.