EFFECT OF BODY-FAT ON EXERCISE HEMODYNAMICS IN SEDENTARY OLDER MEN

Morbid obesity is often associated with cardiac dilatation and left ve ntricular dysfunction. The present study investigated whether a simila r relationship exists between mild and moderate obesity and left ventr icular reserve function in 28 middle aged and older men (58.6+/-6.1 ye ars, mean+/-SD). Subjects had a body mass index of 26.4+/-2.9 kg/m(2), ct percent body fat determined by hydrodensitometry ranging from 9.5% to 33.8%, and were carefully screened to exclude cardiovascular disea se. Left ventricular function was assessed by gated blood pool scans a t rest and during exhaustive upright cycle exercise. There were no sig nificant relationships between resting or exercise cardiac volumes or ejection fraction with percent body fat; however, peak work rate/kg co rrelated inversely with percent body fat (r=-0.68, p<0.0001), Heart ra te reserve, defined as heart rate at peak work rate minus resting hear t rate, declined significantly with increasing percent body fat (r=-0. 47, p=O.01). End diastolic volume index reserve also tended to decline with increasing percent body fat, but stroke volume index and cardiac index reserve were maintained because the decrease in end systolic vo lume index from rest to maximal exercise was greatest in those subject s with highest percent body fat (r=-0.41, p=0.03). Therefore, rest and exercise left ventricular function are not related to percent body fa t in healthy older men. However; older more obese men have a smaller i ncrease in heart rate and end diastolic volume and a greater decrease in end systolic volume from rest to peak effort as ct mechanism to aug ment exercise cardiac output.