Primary prevention of thrombosis in subjects with positive antiphospholipid antibodies

A major cause of stroke, as well as other arterial and venous thromboemboli c disease has been identified-the presence of antiphospholipid antibodies ( aPL). Now it is possible to identify individuals positive for aPL and still free of thrombosis. The tests to measure aPL have been standardized (aCL b y ELISA and LA by coagulometric assays) and they are routinely performed in patients with SLE and other connective tissue diseases and women with recu rrent pregnancy loss. However, very little is known about the risk of throm bosis in individuals positive for aPL but still free of thrombosis. Should these individuals receive any treatment? If so, which one? (C) 2000 Academi c Press.