Non-aqueous capillary electrophoresis

The benefits of non-aqueous capillary electrophoresis have been described i n a number of recent publications. The wide selection of organic solvents, with their very different physicochemical properties, broadens our scope to manipulate separation selectivity. The lower currents present in non-aqueo us solvents allow the use of high electric field strengths and wide bore ca pillaries, the latter in turn allowing larger sample load. In many cases de tection sensitivity can also be enhanced. The potential of non-aqueous capi llary electrophoresis is discussed throughout the paper, and the feasibilit y of capillary electrophoresis under non-aqueous media is demonstrated with reference to several applications. (C) 2000 Elsevier Science B.V. All righ ts reserved.