Hepatoprotective activity of Emblica officinalis and Chyavanaprash

Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CH Y) extracts were studied using carbon tetrachloride (CCl4) induced liver in jury model in rats. EO and CHY extracts were found to inhibit the hepatotox icity produced by acute and chronic CCl4 administration as seen from the de creased levels of serum and liver lipid peroxides (LPO), glutamate-pyruvate transaminase (GPT), and alkaline phosphatase (ALP). Chronic CCl4 administr ation was also found to produce liver fibrosis as seen from the increased l evels of collagen hydroxyproline and pathological analysis. EO and CHY extr acts were found to reduce these elevated levels significantly, indicating t hat the extract could inhibit the induction of fibrosis in rats. (C) 2000 E lsevier Science Ireland Ltd. All rights reserved.