Oral hypoglycaemic activity of Ipomoea aquatica

Ipomoea aquatica is a commonly consumed green leafy vegetable in Sri Lanka which is supposed to possess an insulin-like activity [Jayaweera, D.M.A., 1 982. Medicinal Plants (Indigenous and Exotic) Used in Ceylon. Part 11. Nati onal Science Council, Colombo, Sri Lanka, pp. 99]. Only a little attention has been paid to the therapeutic use of this plant. We studied the oral hyp oglycaemic activity of single and multiple doses of I. aquatica in healthy, male Wistar rats after a glucose challenge. There was a significant reduct ion in the serum glucose concentrations with both single (33%, P < 0.0027) and multiple (25%, P < 0.02) doses. The optimum dose was 3.4 g/kg while the optimum activity was given 2 h after the administration of the extract. Th e present study indicates that a boiled, whole extract of I. aquatica exert s an oral hypoglycaemic effect in healthy, male, Wistar rats after a glucos e challenge. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.