The chronic proliferative dermatitis mouse mutation (cpdm): mapping of themutant gene locus

The chronic proliferative dermatitis (cpdm) mouse mutation was mapped to mo use Chromosome 15 using an intraspecific cross between C57BL/KaLawRij cpdm/ cgdm and BALB/cJ mice. A second autosomal recessive mutation that resulted in a phenotype similar to that of cpdm arose spontaneously in a colony of O cB-3/Dem recombinant congenic mice. This new mutation was found to be allel ic with cpdm. Therefore, the gene symbol for the allelic mutation is cpdm(D em). The phenotype of these mutant mice consists of eosinophil-driven sever e and progressive inflammatory changes in multiple organs including the ski n and lungs.