Synthesis and characterization of a diruthenium-ibuprofenato complex - Comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex

The ibuprofen complex of diruthenium(II,III) was prepared and characterized by electronic (UV-Vis) and vibrational (FTIR spectroscopies and thermograv imetry. The copper(II)-ibuprofenato complex was prepared by a different rc, ute from that described in the literature. Both complexes were tested in vi vo for anti-inflammatory activity. Oral administration of the two complexes inhibited development of carrageenin-induced edema in rats, this inhibitio n being similar to that observed for oral administration of the parent drug (free ibuprofen). However, gastric irritation was lower as compared to tha t of ibuprofen. Diruthenium-ibuprofenato exhibited a protective effect at l ight intensity ulceration while the copper-ibuprofenato complex was more ef fective in the:protection of severe intensity ulceration. (C) 2000 Elsevier Science S.A. All rights reserved.