Mb. Ferrari et al., Synthesis, structural characterization and biological activity of p-fluorobenzaldehyde thiosemicarbazones and of a nickel complex, J INORG BIO, 81(1-2), 2000, pp. 89-97
New thiosemicarbazones (1-7), derived from p-fluorobenzaldehyde and differe
ntly substituted thiosemicarbazides, were synthetized and characterized by
means of NMR and IR techniques. The p-fluorobenzaldehyde thiosemicarbazone
Hfbt (1), the p-fluorobenzaldehyde 4-phenylthiosemicarbazone Ph-Hfbt (4) an
d complex [Ni(fbt)(2)] (8) were also characterized by X-ray diffractometry.
Molecules 1 and 4 consist of two units: the p-fluorobenzaldehyde residue a
nd the thiosemicarbazonic chain. In the reaction of 1 with NiAc2.4H(2)O, co
mplex 8 was afforded. The molecular structure of 8 consists of the neutral
molecules [Ni(fbt)(2)] with the metal placed on a symmetry centre, The coor
dination results in a square planar configuration and involves the sulphur
atom and the hydrazine nitrogen atom of the two ligands in a trans configur
ation. Moreover, for compounds 1, 2, 4, and 8. assays of proliferation inhi
bition and apoptosis tests in vitro on human leukemia cell line U937 were c
arried out. (C) 2000 Elsevier Science S.A. All rights reserved.