QSAR based on biological microcalorimetry

In this paper we describe a QSAR based on biological microcalorimetry for a set of antimicrobial hydrazides acting against Saccharomyces cerivisiae an d Escherichia coli. Results show that an extrathermodynamic relationship ex ists based upon partitioning (log PTA and microcalorimetrically measured bi opotencies using the same cell systems. Moreover, the extrathermodynamic re lationship between drug potencies for these two cell systems shows that bot h cellular systems appear to behave in the same way with respect to the imp ortance of partitioning. This means that the same set of congeneric compoun ds experience a similar environment in the two systems. This represents a l ateral validation of the method and discloses the validity of the QSAR mode l.