A trial of oats in children with newly diagnosed celiac disease

Objective: To determine whether consumption of oats is safe in children wit h newly diagnosed celiac disease who are starting a gluten-free diet. Study design: We conducted a self-controlled, open-label, 6-month trial of a commercial oat breakfast cereal product. Primary outcome variables were s mall bowel histomorphology and anti-tissue transglutaminase IgA antibody ti ter. Results: The 10 children who completed the study were 6.8 +/- 4.0 (mean +/- SD) years of age and 5 were male. Over 6.6 +/- 0.7 months, they consumed 2 4 grams of oat cereal per day, or 1.2 +/- 9.9 g/kg/d. Compared with start o f study, at completion there was a significant decrease in biopsy score (P < .01), intra-epithelial lymphocyte count (P < .005), anti-tissue transglut aminase IgA antibody titer (P < .01), and number of symptoms (P < .01). Conclusions: We conclude that consumption of a commercially available oat c ereal product for 6 months is safe for children with cel;ac disease beginni ng a gluten-free diet. Studies are needed to determine the long-term safety of including oat cereal in the gluten-free diet.