Laparoscopic versus open radical nephrectomy: A 9-year experience

Purpose: The laparoscopic approach for renal cell carcinoma is slowly evolv ing. We report our experience with laparoscopic radical nephrectomy and com pare it to a contemporary cohort of patients with renal cell carcinoma who underwent open radical nephrectomy. Materials and Methods: From 1990 to 1999, 32 males and 28 females underwent 61 laparoscopic radical nephrectomies for suspicious renal cell carcinoma. Clinical data from a computerized database were reviewed and compared to a contemporary group of 33 patients who underwent open radical nephrectomy f or renal cell carcinoma. Results: Patients in the laparoscopic radical nephrectomy group had signifi cantly reduced, estimated blood loss (172 versus 451 ml., p <0.001), hospit al stay (3.4 versus 5.2 days, p <0.001), pain medication requirement (28.0 versus 78.3 mg., p <0.001) and quicker return to normal activity than patie nts in the open radical nephrectomy group (3.6 versus 8.1 weeks, p <0.001), The majority of laparoscopic specimens (65%) were morcellated. Operating t ime and cost were higher in the laparoscopic than the open nephrectomy grou p. Average followup was 25 months (range 3 to 73) for the laparoscopic and 27.5 months (range 7 to 90) for the open group. Renal cell carcinoma in 3 p atients (8%) recurred in the laparoscopic group versus renal cell, carcinom a in 3 (9%) in the open group. When stratified patients with tumors larger than 4 to 10 cm. experienced similar benefits and results as patients with tumors less than or equal to 4 cm. To date there have been no instances of trocar or intraperitoneal seeding in the laparoscopic radical nephrectomy g roup. Conclusions: Laparoscopic radical nephrectomy, although technically demandi ng, is a viable alternative for managing localized renal tumors up to 10 cm . It affords patients with renal tumors an improved postoperative course wi th less pain and a quicker recovery while providing similar efficacy at 2-y ear followup for patients with T1 and T2 tumors.