Parvovirus B19 infection associated with the production of anti-neutrophilcytoplasmic antibody (ANCA) and anticardiolipin antibody (aCL)

We described four patients who had clinical diagnosis of erythema infectios um and presented with skin rash, polyarthralgia, polyarthritis, and mild fe ver. Anti-parvovirus B19 IgM and IgG antibodies were found in all four pati ents and parvovirus B19 DNA was detected in three of the four patients by p olymerase chain reaction (PCR) in sera using standard methods. Anticardioli pin antibody (aCL) was positive in three of the four patients included thre e with anti-beta 2 glycoprotein I (beta 2GPI). The immunoglobulin isotype o f aCL was found to be IgM. Anti-neutrophil cytoplasmic antibody (ANCA) incl uded three p-ANCA and one c-ANCA was detected in all four patients by indir ect immunofluoresence (IIF). Both anti-proteinase 3 (PR3) and anti-myeloper oxidase (MPO) antibodies were found in two patients whom had polyarthritis for more than 6 months. These data indicate parvovirus B19 may be linked to the induction of an autoimmune response.