Quantification of [carbonyl-C-11]WAY-100635 binding: Considerations on thecerebellum

The specific binding of [carbonyl-C-11]WAY-100635 to 5-hydroxytryptamine(1A ) receptors was quantitated using different kinetic models. Ten healthy sub jects were studied using a GE Advance PET scanner. We suggest that tissue h eterogeneity explains part of the nonspecific binding seen in cerebellum, w hich leads to an underestimation of binding potential with reference tissue methods. The nonlinear three-compartmental model with metabolite-corrected plasma input provides accurate estimates of receptor binding because of th e favorable kinetics of tracer in the brain and circulation. NUCL MED BIOL 27;5:483-486, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.