The specific binding of [carbonyl-C-11]WAY-100635 to 5-hydroxytryptamine(1A
) receptors was quantitated using different kinetic models. Ten healthy sub
jects were studied using a GE Advance PET scanner. We suggest that tissue h
eterogeneity explains part of the nonspecific binding seen in cerebellum, w
hich leads to an underestimation of binding potential with reference tissue
methods. The nonlinear three-compartmental model with metabolite-corrected
plasma input provides accurate estimates of receptor binding because of th
e favorable kinetics of tracer in the brain and circulation. NUCL MED BIOL
27;5:483-486, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.