DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF CARBOHYDRATE-BASED MIMETICS OF CRGDFV

Authors
NICOLAOU KC TRUJILLO JI CHIBALE K
Citation
Kc. Nicolaou et al., DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF CARBOHYDRATE-BASED MIMETICS OF CRGDFV, Tetrahedron, 53(26), 1997, pp. 8751-8778
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
26
Year of publication
1997
Pages
8751 - 8778
Database
ISI
SICI code
0040-4020(1997)53:26<8751:DSABEO>2.0.ZU;2-5
Abstract
The design, synthesis and preliminary biological evaluation of carbohy drate-based non-peptide mimetics of the potent peptidic antagonist of alpha(v) beta(3), and alpha(v) beta(5), pentapeptide cRGDFV (1) is pre sented. The design was based on the NMR-determined structure of 1. (C) 1997 Elsevier Science Ltd.