REDUCTION OF 2-ACYLAZIRIDINES BY SAMARIUM(II) IODIDE - AN EFFICIENT AND REGIOSELECTIVE ROUTE TO BETA-AMINO CARBONYL-COMPOUNDS

Authors
MOLANDER GA STENGEL PJ
Citation
Ga. Molander et Pj. Stengel, REDUCTION OF 2-ACYLAZIRIDINES BY SAMARIUM(II) IODIDE - AN EFFICIENT AND REGIOSELECTIVE ROUTE TO BETA-AMINO CARBONYL-COMPOUNDS, Tetrahedron, 53(26), 1997, pp. 8887-8912
Citations number
47
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
26
Year of publication
1997
Pages
8887 - 8912
Database
ISI
SICI code
0040-4020(1997)53:26<8887:RO2BSI>2.0.ZU;2-#
Abstract
A convenient method for the reduction of 2-acylaziridines, aziridine-2 -carboxylates and aziridine-2-carboxamides is described. The reduction of all of the substrates examined was extremely rapid and highly regi oselective, giving rise to beta-amino carbonyl compounds. This method appears to be general for all of the classes of aziridines mentioned a bove, and also tolerates a variety of nitrogen protecting groups. (C) 1997 Elsevier Science Ltd.