EFFECTS OF PYRUVATE-BASED OR LACTATE-BASED PERITONEAL-DIALYSIS SOLUTIONS ON NEUTROPHIL INTRACELLULAR PH

Acidic (pH 5.2) incubation mixtures containing pyruvate-based or lacta te-based peritoneal dialysis solutions (PDSN's) induced comparable deg rees of intracellular acidosis in neutrophils. However, addition of an acidic (pH 5.2), pyruvate-based PDSN to a pH-7.4, neutrophil/phosphat e-buffered saline mixture brought about higher extracellular and intra cellular (neutrophil) pH values when compared to the introduction of a n equally acidic, lactate-based PDSN. This poor ability of acidic (pH 5.0-5.5), pyruvate-based PDSN's to resist alkalinizing influences is t he cause for the above higher pH values. The higher intracellular pH l evels so obtained may be a reason behind why acidic, pyruvate-based PD SN appear to be more biocompatible than their equally acidic, lactate- based counterparts.