D. Jegger et al., Assembly of the Heparin Removal Device for patients with suspected adversereaction to protamine sulphate, PERFUSION-U, 15(5), 2000, pp. 453-456
Protamine sulphate is routinely used after cardiopulmonary bypass (CPB) to
restore the patient's baseline coagulatory state. However, adverse reaction
s are encountered, and alternative means to neutralize heparin are, therefo
re, necessary. The Heparin Removal Device (HRD) constitutes an extracorpore
al circuit that allows ex vivo deheparinization by mean of a polycationic l
igand that binds heparin molecules.
This paper presents the setup of the HRD circuit. It is illustrated by the
report of a 68-year-old man with a known severe crustacean allergy. The pat
ient (78 kg, 170 cm) was admitted for elective coronary artery bypass graft
surgery. It was decided that the HRD would be used as a precaution in orde
r to avoid the risks of using protamine sulphate. The CPB time and aortic c
rossclamp time were 70 and 40 min, respectively. At the end of CPB. the dev
ice was inserted and processing started. Activated coagulation time values
were monitored over a 130 min period and diminished from 480 to 300 s after
45 min, 220 s after 90 min, and settled at 150 s. Haemostasis was acceptab
le and processing stopped. The operation was terminated and the patient tra
nsferred to the intensive care unit. Clinical evolution was excellent, with
minimal postoperative bleeding.
The HRD presents an alternative to protamine sulphate when this drug is con
traindicated for a certain patient population who might have a suspected, k
nown or emergency adverse reaction.