The development of the method for the determination of terbinafine in cat's plasma and hair

Clinical investigations of terbinafine indicate its high treatment activity against infections by several dermatophytes. Its efficiency was tested als o in the treatment of microsporosis in cats. The distribution of terbinafin e in cat's plasma and hair is important for the identification of the drug efficiency. A fast and reliable reversed-phase high performance liquid chro matographic method with appropriate sample preparation has been developed. Reliability, good reproducibility and low detection limit CLOD 0.25 ng/ml) of the method enable determination of terbinafine in hair and also in plasm a of cats infected with Microsporum canis treated by Lamisil(R) tablets.