Multiple endocrine neoplasia type 1

The recent cloning of the gene responsible for multiple endocrine neoplasia type 1 (Men 1) has opened new avenues for both clinical and basic science research in the field of endocrine oncology. A large amount of genetic info rmation, particularly those in relation to germline and somatic mutations, has since been published during the last 2 years. This new knowledge has pr ovided important insights into its gene function. The significance of these advances in relation to clinical management and future directions for rese arch is discussed.