Although osteosarcoma is the most common primary bone malignancy of childho
od and adolescence that is not related to marrow cells, involvement of the
short tubular bones is uncommon. In contrast to more conventional sites, wh
ere the tumor is usually high grade and found in adolescents, osteosarcoma
of the small bones is more likely to be low grade, and is often seen in old
er individuals. We present a case of low-grade primary osteosarcoma of a me
tatarsal bone in a 25-year-old woman.