Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Authors
Lees, CJ Apostolopoulos, V Acres, B Ramshaw, I Ramsay, A Ong, CS McKenzie, IFC
Citation
Cj. Lees et al., Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice, VACCINE, 19(2-3), 2000, pp. 158-162
Citations number
14
Categorie Soggetti
Veterinary Medicine/Animal Health",Immunology
Journal title
VACCINE
ISSN journal
0264410X → ACNP
Volume
19
Issue
2-3
Year of publication
2000
Pages
158 - 162
Database
ISI
SICI code
0264-410X(20000915)19:2-3<158:IWMAII>2.0.ZU;2-7
Abstract
Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8(+) cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic;mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this incr eased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice. (C) 2000 Elsevier Science Ltd. All rights reserved.