STOBADINE PRETREATMENT ENHANCES GLUTATHIONE-PEROXIDASE ACTIVITY IN THE HEART OF IRRADIATED MICE

Authors
KOVACIKOVA Z CHORVATOVICOVA D GINTER E
Citation
Z. Kovacikova et al., STOBADINE PRETREATMENT ENHANCES GLUTATHIONE-PEROXIDASE ACTIVITY IN THE HEART OF IRRADIATED MICE, Methods and findings in experimental and clinical pharmacology, 19(4), 1997, pp. 241-243
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
19
Issue
4
Year of publication
1997
Pages
241 - 243
Database
ISI
SICI code
0379-0355(1997)19:4<241:SPEGAI>2.0.ZU;2-E
Abstract
The effect of pretreatment with stobadine (a novel drug with cardiopro tective properties) on the activity of glutathione peroxidase was stud ied in the heart of mice after Co-60 irradiation. Exposure to 6.5 cy c aused significant decrease in the activity of the enzyme (p<0.01). Tre atment with stobadine (70.07 mg/kg) 1 or 2 h before irradiation result ed in activity enhancement in comparison with the nonpretreated irradi ated group (p<0.01). We conclude that the radical scavenging mechanism may be involved in the protection exerted by stobadine. The results a re in agreement with those obtained by the micronucleus test.