Z. Kovacikova et al., STOBADINE PRETREATMENT ENHANCES GLUTATHIONE-PEROXIDASE ACTIVITY IN THE HEART OF IRRADIATED MICE, Methods and findings in experimental and clinical pharmacology, 19(4), 1997, pp. 241-243
The effect of pretreatment with stobadine (a novel drug with cardiopro
tective properties) on the activity of glutathione peroxidase was stud
ied in the heart of mice after Co-60 irradiation. Exposure to 6.5 cy c
aused significant decrease in the activity of the enzyme (p<0.01). Tre
atment with stobadine (70.07 mg/kg) 1 or 2 h before irradiation result
ed in activity enhancement in comparison with the nonpretreated irradi
ated group (p<0.01). We conclude that the radical scavenging mechanism
may be involved in the protection exerted by stobadine. The results a
re in agreement with those obtained by the micronucleus test.