Oral involvement in mycosis fungoides: Report of two cases and a literature review

Oral involvement is uncommon in cutaneous T-cell lymphomas and usually asso ciated with poor prognosis. The clinicopathological and immunohistochemical findings of 2 new cases are described along with a literature review. The first patient had a 10-year history of mycosis fungoides when she developed lesions in the oral tissues. She died 6 months later despite treatment. Th e immunophenotype was CD3(+), CD4(+), CD8(-), CD30(-). The second patient h ad a mycosis fungoides for 5 years when she developed lesions in the uvula and oropharynx, She was treated with polychemotherapy and she is alive 5 ye ars after oral involvement. The immunophenotype was CD3(+), CD4(-), CD8(+) CD30(-). There are conflicting reports about the prognosis in the CDS8(+) p henotype. The present cases and the literature review seem to indicate that in oral involvement the CD8(+) phenotype is not associated with a worse pr ognosis than the CD4(+) subtype, However, it is necessary to study new case s to confirm this statement.