M. Gille et al., ACUTE ENCEPHALOMYOPATHY AND PERMANENT CER EBELLAR SYNDROME FOLLOWING LITHIUM AND HALOPERIDOL INTOXICATION, Revue neurologique, 153(4), 1997, pp. 268-270
A 44-year-old maniacodepressive woman developed acute encephalopathy d
ue to the association of lithium carbonate and haloperidol. She was tr
eated with lithium salts for many years and the serum level of lithium
was within the therapeutic range. The encephalopathy was worsened by
hyperthermia, dehydration, and reintroduction of haloperidol, 5 days a
fter the first discontinuation of the neuroleptic. The clinical featur
es were characterized by a persistent cerebellar syndrome, more than o
ne year after the interruption of these medications.