Circulating levels of TNF alpha and TNF receptor superfamily members in lymphoid neoplasia

We have correlated the serum levels of TNF alpha and soluble TNF receptor s uperfamily members with clinico-pathologic parameters in patients of Hodgki n's disease (HD, N = 26) and non-Hodgkin's lymphoma (NHLs, N = 35), HD pati ents had significantly higher levels of TNF alpha, sTNFRI, and sTNFRII in s erum while NHL patients had significantly higher levels of sTNFRI, sTNFRII, sCD27, and sFas as compared to controls. in NHL patients the levels of sCD 27 correlated directly and significantly with the high-stage disease, bone marrow involvement, lymph nodal presentation, and serum LDH levels. Similar ly in NHL patients, levels of sFas also correlated directly and significant ly with the presence of high stage disease. HD patients with B symptoms had significantly higher levels of sTNFRII. (C) 2000 Wiley-Liss, Inc.