Ai. Holodny et al., The effect of brain tumors on BOLD functional MR imaging activation in theadjacent motor cortex: Implications for image-guided neurosurgery, AM J NEUROR, 21(8), 2000, pp. 1415-1422
Citations number
27
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Neurosciences & Behavoir
BACKGROUND AND PURPOSE: Functional MR (fMR) imaging data coregistered to a
neurosurgical navigation system have been proposed as guides for the resect
ion of brain tumor in or adjacent to eloquent cortices, The purpose of this
study was to compare data obtained from the side of the brain affected by
tumor with the contralateral side and to determine if there are physiologic
al limitations of fMR imaging in accurately determining the location of the
primary motor cortex.
METHODS: Ten patients with tumors in or directly adjacent to the motor cort
ex were studied with fMR imaging (finger-tapping paradigm). fMR imaging dat
a were analyzed using multiple R values. These data were coregistered to a
real-time intraoperative neurosurgical navigation system.
RESULTS: Significant variability of motor cortex activation patterns was no
ted among individual patients. The activation volumes on the side of the tu
mor were significantly smaller compared with the contralateral side for all
tumors not previously resected (0.66+/-0.47). This was most pronounced in
glioblastomas (0.27+/-0.21). We propose that these differences were caused
by a loss of autoregulation in the tumor vasculature of glioblastomas and v
enous effects.
CONCLUSION: Notwithstanding the differences noted, the motor cortex was ide
ntified successfully in all patients. This was confirmed by intraoperative
physiological identification of the motor cortex and a lack of postoperativ
e neurologic deficit.