Cerebellar cortical dysplasia: MR findings in a complex entity

Citation
G. Soto-ares et al., Cerebellar cortical dysplasia: MR findings in a complex entity, AM J NEUROR, 21(8), 2000, pp. 1511-1519
Citations number
24
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Neurosciences & Behavoir
Journal title
AMERICAN JOURNAL OF NEURORADIOLOGY
ISSN journal
01956108 → ACNP
Volume
21
Issue
8
Year of publication
2000
Pages
1511 - 1519
Database
ISI
SICI code
0195-6108(200009)21:8<1511:CCDMFI>2.0.ZU;2-4
Abstract
BACKGROUND AND PURPOSE: MR imaging findings of cerebellar cortical dysplasi a have been described as a new cerebellar malformation. The purpose of this study was to assess the association of cerebellar cortical dysplasia with other cerebral malformations. METHODS: We retrospectively reviewed 46 MR examinations of patients present ing with developmental delay, hypotonia, and facial deformities to identify abnormal folia or fissures or both within cerebellar hemispheres or vermis suggesting cortical dysplasia. RESULTS: Cerebellar cortical dysplasia was diagnosed in 17 patients. In two patients, it was isolated. In the remaining 15 patients, the malformation was associated with vermian malformation (n=11), cerebral cortical dysplasi as (n=8), dysplasia of corpus callosum (n=6), and heterotopia (n=5). A wide spread malformation of the posterior fossa was observed in eight patients ( Dandy-Walker, Chiari II and III, and hypoplasia of brain stem). One patient with hypertrophied cerebellar hemisphere had minor enlargement of the righ t cerebral hemisphere and lateral ventricle, He also had nodular heterotopi a, suggesting unilateral megalencephaly. CONCLUSION: Our study suggests that cerebellar cortical dysplasias are comm on in cases with more widespread cerebral malformations. Technical progress providing high-quality tridimensional MR imaging of the cerebellum may exp lain its recent descriptions.