The case reports of 17-year-old female dizygotic twins are presented, One o
f the twins had bilateral closed-lip schizencephaly, and the other had foca
l cortical dysplasia, Septum pellucidum was absent in both cases. The corti
cal dysplasia in case 2 corresponded to the same hemispheric location with
the right schizencephalic cleft in case 1. The combination of schizencephal
y and focal cortical dysplasia in siblings or twins has not been previously
reported.