P. Segers et al., Left ventricular wall stress normalization in chronic pressure-overloaded heart: a mathematical model study, AM J P-HEAR, 279(3), 2000, pp. H1120-H1127
Citations number
36
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
It is generally accepted that the left ventricle (LV) hypertrophies (LVH) t
o normalize systolic wall stress (sigma(s)) in chronic pressure overload. H
owever, LV filling pressure (Pv) may be elevated as well, supporting the al
ternative hypothesis of end-diastolic wall stress (sigma(d)) normalization
in LVH. We used an LV time-varying elastance model coupled to an arterial f
our-element lumped-parameter model to study ventricular-arterial interactio
n in hypertension-induced LVH. We assessed model parameters for normotensiv
e controls and applied arterial changes as observed in hypertensive patient
s with LVH (resistance +40%, compliance -25%) and assumed 1) no cardiac ada
ptation, 2) normalization of sigma(s) by LVH, and 3) normalization of sigma
(s) by LVH and increase in P-v, such that sigma(d) is normalized as well. I
n patients, systolic and diastolic blood pressures increase by similar to 4
0%, cardiac output (CO) is constant, and wall thickness increases by 30-55%
. In scenarios 1 and 2, blood pressure increased by only 10% while CO dropp
ed by 20%. In scenario 2, LV wall thickness increased by only 10%. The pred
ictions of scenario 3 were in qualitative and quantitative agreement with i
n vivo human data. LVH thus contributes to the elevated blood pressure in h
ypertension, and cardiac adaptations include an increase in P-v, normalizat
ion of sigma(s), and preservation of CO in the presence of an impaired dias
tolic function.