NMDA channel blockers: memantine and amino-aklylcyclohexanes - In vivo characterization

Authors
Danysz, W Parsons, CG Quack, G
Citation
W. Danysz et al., NMDA channel blockers: memantine and amino-aklylcyclohexanes - In vivo characterization, AMINO ACIDS, 19(1), 2000, pp. 167-172
Citations number
26
Categorie Soggetti
Biochemistry & Biophysics
Journal title
AMINO ACIDS
ISSN journal
09394451 → ACNP
Volume
19
Issue
1
Year of publication
2000
Pages
167 - 172
Database
ISI
SICI code
0939-4451(2000)19:1<167:NCBMAA>2.0.ZU;2-I
Abstract
The previous overviews provided the basis for better therapeutic efficacy/t olerability of low to moderate affinity NMDA channel blockers. This predict ion finds support in in vitro studies comparing protective and plasticity i mpairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. Bu t can it be confirmed in the in vivo situation?