The clinical pharmacology of alkylating agents in high-dose chemotherapy

Authors
Huitema, ADR Smits, KD Mathot, RAA Schellans, JHM Rodenhuis, S Beijnen, JH
Citation
Adr. Huitema et al., The clinical pharmacology of alkylating agents in high-dose chemotherapy, ANTI-CANC D, 11(7), 2000, pp. 515-533
Citations number
207
Categorie Soggetti
Pharmacology,"Onconogenesis & Cancer Research
Journal title
ANTI-CANCER DRUGS
ISSN journal
09594973 → ACNP
Volume
11
Issue
7
Year of publication
2000
Pages
515 - 533
Database
ISI
SICI code
0959-4973(200008)11:7<515:TCPOAA>2.0.ZU;2-5
Abstract
Alkylating agents are widely used in high-dose chemotherapy regimens in com bination with hematological support. Knowledge about the pharmacokinetics a nd pharmacodynamics of these agents administered in high doses is critical for the safe and efficient use of these regimens. The aim of this review is to summarize the clinical pharmacology of the alkylating agents (including the platinum compounds) in high-dose chemotherapy. Differences between con ventional and high doses will be discussed. [(C) 2000 Lippincott Williams & Wilkins].