Jf. Morere et al., Dose-finding study of paclitaxel and carboplatin in patients with advancednon-small cell lung cancer, ANTI-CANC D, 11(7), 2000, pp. 541-548
This dose-finding study was designed to determine the maximum tolerated dos
e (MTD), efficacy and toxicity of combined paclitaxel and carboplatin in 35
previously untreated patients with advanced non-small cell lung cancer (NS
CLC). Paclitaxel was given as a 3-h infusion at escalating dose levels (100
-250 mg/m(2)) immediately followed by carboplatin as a 30-min infusion (325
or 350 mg/ m(2)) every 3 weeks. The dose-limiting toxicity, paresthesia, o
ccurred at the highest dose level, therefore the recommended dose was estab
lished one level below (paclitaxel 225 mg/m(2) with carboplatin 325 mg/m(2)
). Neutropenia was the most common hematotoxicity; dose dependency was not
apparent. Two patients, at different dose levels, had febrile neutropenia.
Thrombocytopenia was rare. Non-hematological toxicities grade 3 or higher i
ncluded infection, anorexia, alopecia and paresthesia. One patient had a hy
persensitivity reaction (transient hypotension). The overall response rate
was 23% and median survival time was 7.5 months. Promising activity and acc
eptable toxicity supports the development of this combination as a useful c
hemotherapeutic option in advanced NSCLC. [(C) 2000 Lippincott Williams & W
ilkins].