Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa

Authors
Pumbwe, L Piddock, LJV
Citation
L. Pumbwe et Ljv. Piddock, Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa, ANTIM AG CH, 44(10), 2000, pp. 2861-2864
Citations number
25
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
10
Year of publication
2000
Pages
2861 - 2864
Database
ISI
SICI code
0066-4804(200010)44:10<2861:TESESI>2.0.ZU;2-Z
Abstract
Simultaneous overexpression of MexAB-OprM and MexEF-OprN was demonstrated f or a multiply antibiotic-resistant clinical isolate of Pseudomonas aerugino sa (G49). G49 also had decreased expression of OprF. No mutations in mexR o r its upstream promoter region, mexT, oprM, oprF, or sigX were revealed, su ggesting regulation by a hitherto undescribed locus.